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Angel Martí

Associate Professor of Chemistry, Bioengineering, and Materials Science and NanoEngineering

Our research group is interested in the design and synthesis of multifunctional molecular constructs for the treatment and diagnosis of amyloid forming diseases such as Alzheimer's and Parkinson's Disease, in addition to the development of sensors and the in vivo and in vitro detection of DNA and mRNA. 5.2 million people suffer Alzheimer's in the United States. By 2050, this number will increase to 14 million unless a cure is found. Finding novel treatments for Alzheimer's disease represents a challenge that will involve different scientific disciplines. Our approach involves the use of molecular scissors to degrade and solubilize amyloid deposits. These amyloid scissors consist of a recognition element capable of selectively binding to amyloid plaques, bound to an artificial protease capable of cleave proteins, similar to those in amyloid plaques. We also aim to attach paramagnetic species such as gadolinium compounds to amyloid recognition elements for use as diagnosis tools in conjuction with MRI techniques. Other projects involve the design of probes for the detection and monitoring of DNA and mRNA in different media. This will include the use of hybridization probes with an oligonucleotide sequence complementary to the target sequence of interest, and a fluorescent reporter group capable of changing its photophysical properties upon binding to the target sequence. Our group is also interested in investigating the changes in structure that the protein alpha-synuclein undergoes when it binds to membranes and small molecules such as melanin. Alpha-synuclein has been associated with the pathology of Parkinson's disease. We will use spectroscopic methods such as FTIR and circular dichroism to determine the changes in structure of this protein when interacting with different molecular and supramolecular agents.


Gupta, B. K.; Singh, S.; Kedawat, G.; Kanika; Kumar, P; Gangwar, A. K.; Narayanan, T. N.; Martí, A. A.; Vajtai, R.; Ajayan, P. M. A Novel Electroluminescent Device Based on Reduced Graphene Oxide Wrapped Phosphor (ZnS:Cu, Al) and Hexagonal-Boron Nitride for High-Performance Luminescence.  Nanoscale, 9 2017: 5002-5008

Klockner, W.; Yadav, R. M.; Yao, J.; Lei, S.; Aliyan, A.; Wu, J.; Martí, A. A.; Vajtai, R.; Ajayan, P. M.; Denardin, J. C.; Serafini, D.; Melo, F.; Singh, D. P. Acetonitrile mediated facile synthesis and self-assembly of silver vanadate nanowires in to 3D spongy like structure as a cathode material for lithium ion battery.  ‎J. Nanopart. Res., 19 2017: 288

Liu, Y.; Liang, C.; Wu, J.; Sharifi, T.; Nakanishi, Y.; Yang, Y.; Aliyan, A.; Martí, A. A.; Xie, B. Chopra, N.; Odeh, I.; Vajtai, R.; Wei, Y.; Ajayan, P. M. Atomic Layered Titanium Sulfide Quantum Dots as Electrocatalysts for Enhanced Hydrogen Evolution Reaction.  Adv. Mater. Interface 2017: DOI: 10.1002/admi.201700895

Xie, Z.; Jiang, C.; Xu, W.; Cui, X.; de los Reyes, C. A.; Martí, A. A.; Wang, Y. Facile Self-Assembly Route to Co3O4 Nanoparticles Confined into Sheet-Like SWCNT Matrix for Highly Reversible Lithium Storage.  Electrochim. Acta , 235 2017: 613-622

Radhakrishnan, S.; Das, D.; Samanta, A.; de los Reyes, C.; Deng, L.; Alemany, L. B.; Weldeghiorghis, T. K.; Khabashesku, V. N.; Jin, Z.; Kochat, V.; Sudeep, P. M.; Martí, A. A.; Chu, C. –W.; Roy, A.; Tiwary, C. S.; Singh, A. K.; Ajayan, P. M. Fluorinated h-BN as magnetic semiconductor.  Sci. Adv., 3 2017: e1700842

Jiang, C.; Peng, Z.; de los Reyes, C.; Young, C. C.; Tsentalovich, D.; Ajayan, P. M.; Tour, J. M.; Pasquali, M.; Martí, A. A. Increased Solubility and Fiber Spinning of Graphenide Dispersions Aided by Crown-Ethers.  Chem Commun., 53 2017: 1498-1501

Abdolvahabi, A.; Shi, Y.; Rasouli, S.; Aliyan, A.; Croom, C. M.; Martí, A. A.; Shaw, B. F. Kaplan–Meier Meets Chemical Kinetics: Intrinsic Rate of SOD1 Amyloidogenesis Decreased by Subset of ALS Mutations and Cannot Fully Explain Age of Disease Onset.  ACS Chem. Neurosci., 8 2017: 1378-1389

Aliyan, A.; Paul, T. J.; Jiang, B.; Pennington, C.; Sharma, G.; Prabhakar, R.; Martí, A. A. Photochemical Identification of Molecular Binding Sites on the Surface of Amyloid-β Aggregates.  Chem, 3 2017: 898-912

García-Lopez, V.; Alemany, L. B.; Chiang, P. –T.; Sun, J.; Chu, P. –L.; Martí, A. A.; Tour, J. M. Synthesis of a Light-Driven Motorized Nanocar for Linear Trajectories and their Detailed NMR Structural Determination.  Tetrahedron , 73 2017: 4864-4873

Gupta, B. K.; Singh, S.; Kumar, P.; Lee, Y.; Kedawat, G.; Narayanan, T. N.; Vithayathil, S. A.; Ge, L.; Zhan, X.; Gupta, S.; Martí, A. A.; Vajtai, R.; Ajayan, P. M.; Kaipparettu, B. A. Bifunctional Luminomagnetic Rare-Earth Nanorods for High-Contrast Bioimaging Nanoprobes.  Sci. Rep., 6 2016: 32401

Huang, K.; Saha, A.; Dirian, K.; Chu, P.-L. E.; Tour, J. M.; Jiang, C.; Guldi, D. M.; Martí, A. A. Carbon Nanotubes Dispersed in Aqueous Solution by Ruthenium(II) Polypyridyl Complexes.  Nanoscale, 8 2016: 13488-13497

García-Lopez, V.; Jeffet, J.; Kuwahara, S.; Martí, A. A.; Ebenstein, Y.; Tour, J. M. Synthesis and Photostability of Unimolecular Submersible Nanomachines: Toward Single-Molecule Tracking in Solution.  Org. Lett., 18 2016: 2343-2346

Aliyan, A.; Kirby, B.; Pennington, C.; Martí, A. A. Unprecedented Dual-Light Switching Response of a Metal Dipyridophenazine Complex Towards Amyloid-β Aggregation.  J. Am. Chem. Soc., 138 2016: 8686-8689

García-Lopez, V.; Chu, P. -L. E.; Chiang, P -T.; Sun, J.; Martí, A. A.; Tour, J. M. Synthesis of a Light-Driven Motorized Nanocar.  Asian J Org Chem., 4 2015: 1308-1314

Abdolvahabi, A.; Shi, Y.; Rhodes, N. R.; Cook, N. P.; Martí, A. A.; Shaw, B. F. Arresting Amyloid with Coulomb’s Law: Acetylation of ALS-Linked SOD1 by Aspirin Impedes Aggregation.  Biophys. J., 108 2015: 1199-1212

Ye, R.; Peng, Z.; Metzger, A.; Lin, J.; Mann, J. A.; Huang, K.; Xiang, C.; Fan, X.; Samuel, E. L. G.; Alemany, L. B.; Martí, A. A.; Tour, J. M. Bandgap Engineering of Coal-Derived Graphene Quantum Dots.  ACS Appl. Mater. Interfaces, 7 2015: 7041-7048

Jiang, C.; Saha, A.; Martí, A. A. Carbon Nanotubides: An Alternative for Dispersion, Functionalization and Composites Fabrication.  Nanoscale, 7 2015: 15037-15045

Ahmed, Z.; Timsah, Z.; Suen, K. M.; Leonard, P. G.; Cook, N. P.; Lee, G. R.; Lin, C.-C.; Gagea, M.; Martí, A. A.; Ladbury, J. E. Grb2 Monomer-Dimer Equilibrium Determines Normal versus Oncogenic Function.  Nat. Commun., 6 2015: 7354

Kovalchuk, A.; Huang, K.; Xiang, C.; Martí, A. A.; Tour, J. M. Luminescent Polymer Composite Films Containing Coal-Derived Graphene Quantum Dots.  ACS Appl. Mater. Interfaces, 7 2015: 26063-23068

Ohata, J.; Vohidov, F.; Aliyan, A.; Huang, K.; Martí, A. A.; Ball, Z. T. Luminogenic Iridium Azide Complexes.  Chem. Commun., 51 2015: 15192-15195

Martí, A. A. Metal Complexes and Time-Resolved Photoluminescence Spectroscopy for Sensing Applications.  J. Photochem. Photobiol. A, 307 2015: 35-47

Godoy, J.; García-López, V.; Wang, L. -Y.; Rondeau-Gagné, S.; Link, S.; Martí, A. A.; Tour, J. M. Synthesis of a Fluorescent BODIPY-Tagged ROMP Catalyst and Initial Polymerization-Propelled Diffusion Studies.  Tetrahedron, 7 2015: 5965-5972

García-Lopez, V.; Chiang, P -T.; Chen, F.; Ruan, G.; Martí, A. A.; Kolomeiski, A. B.; Wang, G.; Tour, J. M. Unimolecular Submersible Nanomachines. Synthesis, Actuation and Monitoring.  Nano Lett., 15 2015: 8229-8239

Kewei, H.; Jiang, C.; Martí, A. A. Ascertaining Free Histidine from Mixtures with Histidine-Containing Biomolecules using Time-Resolved Photoluminescence Spectroscopy.  J. Phys. Chem. A, 118 2014: 10353-10358

Saha, A.; Jiang, C.; Martí, A. A. Carbon Nanotube Networks on Different Platforms.  Carbon, 79 2014: 1-18

Hwang, C. -C.; Ruan, G.; Wang, L.; Zheng, H.; Samuel E. L. G.; Xiang, C.; Wei, L.; Kasper, W.; Huang, K.; Peng, Z.; Schaefer, Z.; Kan, A. T.; Martí, A. A.; Wong, M. S.; Tomson, M. B.; Tour, J. M. Carbon-based Nanoreporters Designed for Subsurface Hydrogen Sulfide Detection.  ACS Appl. Mater. Interfaces, 6 2014: 7652-7658

Jiang, C.; Saha, A.; Young, C. C.; Hashim, D. P.; Ramirez, C.; Ajayan, P. M.; Pasquali, M.; Martí, A. A. Macroscopic Nanotube Fibers Spun from Single-Walled Carbon Nanotube Polyelectrolites.  ACS Nano, 8 2014: 9107-9112

Mondal, P.; Ghosal, K.; Bhattacharyya, S. K.; Das, M.; Bera, A.; Ganguly, D.; Kumar, P.; Dwivedi, J.; Gupta, R. K.; Martí, A. A.; Gupta, B. K.; Maiti, S. ormation of a Gold–Carbon Dot Nanocomposite with Superior Catalytic Ability for the Reduction of Aromatic Nitro Groups in Water.  RSC Adv., 4 2014: 25863-25866

Saha, S.; Panos, Z.; Hanna, T.; Huang, K.; Hernández-Rivera, M.; Martí, A. A. 3-Dimensional Solvent Vapor Map Generated by Supramolecular Metal Complex Entrapment.  Angew. Chem. Int. Ed., 52 2013: 12615-12618

Shi, Y.; Rhodes, N. R.; Kohn, T.; Cook, N. P.; Abdovahabi, A.; Mowery, R. A.; Martí, A. A.; Shaw, B. F. Asparagine Deamidation in Wild-Type SOD1 can Mimic the Biophysical Effects of Mutations that Cause Amyotrophic Lateral Sclerosis.  J. Am. Chem. Soc., 135 2013: 15897-15908

Ye, R.; Xiang, C.; Lin, J.; Peng, Z.; Huang, K.; Yan, Z.; Cook, N. P.; Samuel, E. L. G.; Hwang, C. -C.; Ruan, G.; Ceriotti, G.; Raji, A. -R. O.; Martí, A. A.; Tour, J. M. Coal as an Abundant Source of Graphene Quantum Dots.  Nat. Commun., 4 2013: 2943

Jiang, C.; Saha, A.; Changsheng, X.; Young, C.; Tour, J. M.; Pasquali, M.; Martí, A. A. Increased Solubility, Diameter Selectivity and Liquid Crystalline Phase of Single-Walled Carbon Nanotube Polyelectrolyte Dispersions.  ACS Nano, 7 2013: 4503-4510

Cook, N. P.; Archer, C. M.; Fawver, J. N.; Schall, H. E.; Rodriguez-Rivera, J.; Dineley, K. T.; Martí;, A. A.; Murray, I. V. J. Ruthenium Red Colorimetric and Birefringent Staining of Amyloid-β Aggregates In Vitro and in Tg 2576 Mice.  ACS Chem. Neurosci., 4 2013: 379-384

Diaz, A.; Mosby, B.; Bakhmutov, V.; Martí, A. A.; Batteas, J.; Clearfield, A. Self Assembled Monolayers Based Upon a Zirconium Phosphate Platform.  Chem. Mater., 25 2013: 723-728

Cook, N. P.; Ozbil, M.; Katsampes, C.; Prabhakar, R.; Martí, A. A. Unraveling the Photoluminescence Response of Light-Switching Ruthenium(II) Complexes Bound to Amyloid-β.  J. Am. Chem. Soc., 135 2013: 10810-10816

Cook, N. P.; Kilpatrick, K.; Segatori, L.; Martí, A. A. Detection of α-Synuclein Amyloidogenic Aggregates In Vitro and in Cells using Light-Switching Dipyridophenazine Ruthenium(II) Complexes.  J. Am. Chem. Soc., 134 2012: 20776-20782

Cook, N. P.; Martí, A. A. Facile Methodology for Monitoring Amyloid-β Fibrillization.  ACS Chem. Neurosci., 3 2012: 896-899

Saha, A.; Ghosh, S.; Weisman, R. B.; Martí, A. A. Films of Bare Single-Walled Carbon Nanotubes from Superacids with Tailored Electronic and Photoluminescence Properties.  ACS Nano, 6 2012: 5727-5734

Peng, J.; Gao, W.; Gupta, B. K.; Liu, Z.; Romero-Aburto, R.; Ge, L.; Song, L.; Alemany, L. B.; Zahn, X.; Gao, G.; Vithayathil, S. A.; Kaipparettu, B. A.; Martí, A. A.; Hayashi, T.; Zhu, J. -J.; Ajayan, P. M. Graphene Quantum Dots Derived from Carbon Fibers.  Nano Lett., 12 2012: 844-849

Gupta, B. K.; Narayanan, T. N.; Vithayathil, S. A.; Lee, Y. Koshy, S.; Reddy, A. L. M.; Saha, A.; Shanker, V.; Singh, V. N.; Kaipparettu, B. A.; Martí, A. A.; Ajayan, P. M. Highly Luminescent-Paramagnetic Nanophosphor Probes for in Vitro High-Contrast Imaging of Human Breast Cancer Cells.  Small, 8 2012: 3028-3034

Huang, K.; Martí, A. A. (Journal Cover) Optimizing the Sensitivity of Photoluminescent Probes Using Time-Resolved Spectroscopy: A Molecular Beacon Case Study.  Anal. Chem., 84 2012: 8075-8082

Reddy, A. L. M.; Gupta, B. K.; Narayanan, T. N.; Martí, A. A.; Ajayan, P. M.; Walker, G. C. Probing on Time-Resolved and Photoluminescence Spectroscopy of Ni Encapsulated Ferromagnetic Boron Nitride Nanotubes.  J. Phys. Chem. C, 116 2012: 12803-12089

Huang, K.; Martí, A. A. Recent Trends in Molecular Beacons Design and Applications.  Anal. Bioanal. Chem., 402 2012: 3091-3102

Huang, K.; Bulik, I.; Martí, A. A. Time-Resolved Photoluminescence Spectroscopy for the Detection of Cysteine and Other Thiol Containing Amino Acids in Complex Strongly Autofluorescent Media.  Chem. Commun., 48 2012: 11760-11762

Jain, D.; Saha, A.; Martí, A. A. (Inside Cover) Non-Covalent Ruthenium Polypyridyl Complexes-Carbon Nanotubes Composites: An Alternative for Functional Dissolution of Carbon Nanotubes in Solution.  Chem. Commun., 47 2011: 2246-2248

Gupta, B. K.; Thanikaivelan, P.; Narayanan, T. N.; Song, L.; Gao, W.; Hayashi, T.; Saha, A.; Shanker, V.; Endo, M.; Martí, A. A.; Ajayan, P. M. Optical Bi-functionality of Europium Complexed Luminescent Graphene Nanosheets..  Nano Lett., 11 2011: 5227-5233

Gupta, B. K.; Rathee, V.; Narayanan, T. N.; Thanikaivelan, P.; Saha, A.; Govind, S.; Singh, P.; Shanker, V.; Martí, A. A.; Ajayan, P. M. Probing a Bifunctional Luminomagnetic Nanophosphor for Biological Applications: a Photoluminescence and Time-Resolved Spectroscopic Study.  Small, 7 2011: 1767-1773

Cook, N. P.; Torres, V.; Jain, D.; Martí, A. A. Sensing Amyloid-ß Aggregation using Luminescent Dipyridophenazine Ruthenium(II) Complexes.  J. Am. Chem. Soc., 133 2011: 11121-11123

Saha, A.; Ghosh, S.; Behabtu, N.; Pasquali, M.; Martí, A. A. Single-Walled Carbon Nanotubes Shell Decorating Porous Silicate Materials: A General Platform for Studying the Interaction of Carbon Nanotubes with Photoactive Molecules.  Chem. Sci., 2 2011: 1682-1687

Angel A. Marti's Research Group

  • Postdoctoral Research Associate (2004-2008) Columbia University, NY
  • B.S. Chemistry (1999) University of Puerto Rico
  • Ph.D. Inorganic Chemistry (2004) University of Puerto Rico
  • Department of Bioengineering
  • Department of Materials Science and NanoEngineering
  • Alzheimer's disease, amyloid, photochemistry, nanotubes, sheets, MOF, fluorescence
Email: aam4@rice.edu
Phone: (713) 348-3486
Office: Dell Butcher Hall, 320B