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Mechanical Genomics: Genome-wide Identification of Regulators of Bacterial Cell Stiffness

Tuesday, September 23, 2014, 12:30 PM - 1:30 PM
Douglas B. Weibel, Associate Professor, University of Wisconsin - Madison

The peptidoglycan (PG) consists of a single, cross-linked layer of polysaccharide that forms the primary load-bearing material of bacteria and resists the large osmotic pressure across the cell wall. As defects in PG assembly and remodeling are catas more  »


In Vivo Imaging and Targeted Drug Delivery With Porous Silicon Nanoparticles

Wednesday, September 17, 2014, 4:00 PM - 5:00 PM
Michael Sailor, Professor of Chemistry and Biochemistry, University of California - San Diego

The electronic and optical properties that make the semiconductor silicon so useful for solid-state devices such as solar cells and microelectronics can also be harnessed for biological applications—in particular in vivo imaging and drug delivery. T more  »


Screening for Noise in Gene Expression Identifies Drug Synergies

Tuesday, September 16, 2014, 12:30 PM - 1:30 PM
Leor Weinberger, Associate Professor, The University of California - San Francisco

Abstract: Over the past decade, a stubborn debate has persisted in biology regarding the role and importance of stochastic gene-expression processes (i.e. "noise"). This roughly parallels the Bohr-Einstein debates that occurred in Physics in the ear more  »


Long Time Dynamics of Biological Molecules

Wednesday, September 10, 2014, 4:00 PM - 5:00 PM
Ron Elber, Professor W.A. ‘Tex’ Moncrief Chair in Computational Life Sciences, University of Texas at Austin

We will show how (many) short trajectory fragments of picosecond lengths can be used to exactly study long time dynamics of biomolecular systems. The short trajectories are used in an exact probabilistic equation that accounts for transitions between more  »


Molecular and Coarse-grained Views of Protein Dynamics in the Unfolded State

Tuesday, September 9, 2014, 12:00 PM - 1:30 PM
Dmitrii E Makarov, Professor, The University of Texas at Austin

Abstract: The nature of the unfolded state of proteins is essential for our understanding of how proteins fold or how intrinsically disordered proteins accomplish their biological function. Computational studies of the unfolded ensemble, however, fac more  »


Chemical Synthesis of Polyhalogenated Natural Products

Monday, September 8, 2014, 4:00 PM - 5:00 PM
Chris Vanderwal, Associate Professor and Chancellor's Fellow, Chemistry School of Physical Sciences, University of California at Irvine

Thousands of halogenated natural products have been characterized. Singly halogenated compounds, whether they are aryl or alkyl halides, do not generally pose a significant challenge for synthesis. There are far fewer polyhalogenated secondary metabo more  »


Selective Functionalization of Alkyl and Aryl C-H Bonds

Wednesday, September 3, 2014, 4:00 PM - 5:00 PM
John Hartwig, Professor of Chemistry, The Henry Rapoport Chair in Organic Chemistry, University of California at Berkeley

Abstract: Our group has developed practical methods for the catalytic functionalization of C-H bonds with main group reagents. This lecture will present a combination of methodology and mechanistic studies that connect these functionalizations with t more  »


Integrating Signaling in Space and Time – Calmodulin as a Case Study

Tuesday, September 2, 2014, 12:30 PM - 1:30 PM
Neal Waxham, Professor, The University of Texas Medical School

Abstract: Cell signaling involves an intricate series of protein-protein associations whose interactions are further complicated by the densely packed and heterogeneous cytoplasm. Protein association is dictated by concentration and diffusion and re more  »


Thesis Defense

Carbon-Based Nanoparticles: Synthesis, Characterization and Applications

Friday, August 29, 2014, 12:00 PM - 2:00 PM
Gabriel Ceriotti, Doctoral Candidate

The presentation will concern the chemistry, applications, and methods for the synthesis of graphene oxide (GO), GO derivatives, graphite derivatives, carbon black derivatives, and activated charcoal derivatives, with an emphasis on applications rele more  »

Thesis Defense

Radiofrequency-induced Cellular Hyperthermia: Water-soluble Fullerene as a New Cancer Therapeutic Agent

Wednesday, August 27, 2014, 2:15 PM - 4:15 PM
Matthew Cheney, Doctoral Candidate

Due to the susceptibility of cancer to hyperthermia, abundant biomedical research is being conducted for the development of therapies using nanotechnology for noninvasive cancer hyperthermia. In this work, the water-soluble and neutrally-charged C60 more  »


Crossing from the Molecular to the Cellular: How Polymers Dictate Cell Shape in Bacteria

Tuesday, August 26, 2014, 12:30 PM - 1:30 PM
Joshua W. Shaevitz, Associate Professor, Princeton University

How bacteria grow into specific, 3D shapes remains a central mystery in microbiology. My group has developed an imaging and analysis pipeline to simultaneously probe the shape of cells and the localization of proteins in 3D during growth. We find evi more  »

Thesis Defense

Anisotropic Noble Metal Nanomaterials for Analytical Surface Enhanced Raman Spectroscopy

Wednesday, August 20, 2014, 2:00 PM - 4:00 PM
Courtney Payne, Doctoral Candidate

Noble metal mesoscale and nanoscale materials exhibit unique optical properties that are of interest to a wide variety of fields including sensing, imaging, biomedicine, and catalysis. The properties of the nanomaterial are strongly dependent on the more  »

Thesis Defense

Rh(II) metallopeptides for asymmetric catalysis

Wednesday, August 20, 2014, 9:00 AM - 11:00 AM
Ramya Sambasivan, Doctoral Candidate

The development of peptides as chiral ligands for asymmetric Rh(II) catalysis is discussed in this work. Mother Nature’s solution to chiral ligand design is to make use of the naturally available chiral building blocks – amino acids. Polypeptides, bu more  »


Thesis Defense

Long-lived Luminescent Metal Complexes for Small Molecules Sensing Application

Monday, July 28, 2014, 1:00 PM - 3:00 PM
Kewei Huang, Doctoral Candidate

The study of long lived emissive probes has been a hot issue within the past few years, since they can improve the sensitivity and accurate of detections by combined with time-resolved photoluminescence spectroscopy (TRPS). Ruthenium and iridium comp more  »