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Total Synthesis and Biological Evaluation of Several Nuphar Alkaloids and their Derivatives

Monday, November 30, 2015, 4:00 PM - 5:00 PM
Jimmy Wu, Dartmouth College

The hydroxylated dimeric nuphar alkaloids are found in the common yellow water lily. In particular, 6-hydroxythiobinupharidine has been shown to induce apoptosis in human leukemia cell lines (U937) faster than any known small molecule.1 However, the more  »


Exciton hopping in semiconducting carbon nanotube solar cells using 2D White-Light Spectroscopy

Monday, November 23, 2015, 4:00 PM - 5:00 PM
Martin Zanni, Ph.D., Professor of Chemistry, University of Wisconsin-Madison

Thin film networks of highly purified semiconducting carbon nanotubes are being explored for energy harvesting and optoelectronic devices because of their exceptional transport and optical properties. The nanotubes in these films are in close contact more  »


Synthetic modification of proteins to create new biomaterials

Thursday, November 19, 2015, 1:00 PM - 2:00 PM
Allie Obermeyer, MIT

The synthetic modification of proteins plays an essential role in the fields of biomaterials science and chemical biology. Conjugation of synthetic molecules to proteins enables the incredible diversity of protein structure and function to be harness more  »


Breaking New Ground with Chiral Alkylboronates: Catalytic Enantioselective Preparation, Cross-Coupling, Synthetic Applications

Wednesday, November 18, 2015, 4:00 PM - 5:00 PM
Dennis Hall, University of Alberta, University of Alberta

Organoboronic acid derivatives are invaluable building blocks that can be synthesized in high yield and exhibit a high-degree of stability over other organometallic reagents. The C–B motif is a well-established precursor of alcohols and amines, and more  »


Solution Processed Semiconductors for Energy: From Organic to Inorganic

Tuesday, November 17, 2015, 1:00 PM - 2:00 PM
Letian Dou, University of California - Berkeley

Solution-processed semiconductors show great promise in energy related applications owing to their synthetic variability, low-temperature processing, and the possibility of producing light-weight, flexible, environmental-friendly, and inexpensive ele more  »


“Cytoskeletal Dynamics and Mechanosensing in Immune Cells”

Tuesday, November 17, 2015, 12:30 PM - 1:30 PM
Arpita Upadhyaya, Associate Professor, Department of Physics, IPST, University of Maryland

Abstract: The activation of lymphocytes is an essential step in the adaptive immune response. Lymphocyte activation involves the binding of specialized receptors (TCR in T cells and BCR in B cells) with antigen on the surface of antigen presenting ce more  »


Necessity is the Mother of Invention: Natural Products and the Chemistry they Inspire

Monday, November 16, 2015, 4:00 PM - 6:00 PM
Sarah Reisman, California Institute of Technology

The chemical synthesis of natural products provides an exciting platform from which to conduct fundamental research in chemistry and biology. Our laboratory has ongoing research programs targeting the chemical syntheses of several natural products, i more  »


IQT 101

Friday, November 13, 2015, 4:00 PM - 5:00 PM
Syd Ulvick

By the late 1990s, the pace of commercial innovation had overtaken the ability of government agencies to develop and incorporate new technologies; the tech industry was innovating far too rapidly to ignore. Commercial technologies from the startup w more  »


New Methods for the Synthesis of Functional Polymeric Materials

Thursday, November 12, 2015, 1:00 PM - 2:00 PM
Frank Leibfarth, Massuchusetts Institute of Technology

We live in a material world. The ubiquity of synthetic polymers is not only proof of their utility, but also evidence of their transformative capacity. The convergence of organic and polymer chemistry holds the key to making materials smarter, more more  »

Thesis Defense

Hybrid and Molecular Plasmonics for Strongly Coupled Nanosystems and Photoelectrochemical Devices

Thursday, November 12, 2015, 2:00 PM - 4:00 PM
Andrea Schlather, Doctoral Candidate

The field of nanophotonics has realized rapid growth over the past several decades, as novel nanoscale materials are consistently being developed and researched for a wide variety of promising light-driven applications. Plasmonics is a particularly f more  »


New Polymers from Old Monomers: Advances Enabled through Catalyst Design and Discovery

Wednesday, November 11, 2015, 4:00 PM - 5:00 PM
Geoffrey Coates, Cornell University

Although the chemical, physical, and mechanical properties of a polymer are the most vital factors in determining utility, another important constraint that must be considered is the cost of the material. The best way to create inexpensive new pol more  »


Molecular Machines with Mechanical Bonds

Tuesday, November 10, 2015, 1:00 PM - 2:15 PM
Carson Bruns, UC Berkeley

The mechanical bond is an entanglement in space between molecular entities that prevents them from being separated, intrinsic to compounds such as catenanes and rotaxanes. The mechanical bond of a rotaxane constrains the translational motion of a mol more  »


“Physical Guidance of Cell Migration”

Tuesday, November 10, 2015, 12:30 PM - 1:30 PM
Angel Garcia, Director, Center for Nonlinear Studies, Los Alamos National Laboratory

Abstract: Cells migrate as individuals or groups, to perform critical functions in life from organ development to wound healing and the immune response. While directed migration of cells is often mediated by chemical or physical gradients, our recen more  »


Chemical Tools for Investigating Biological H2S

Monday, November 9, 2015, 4:00 PM - 5:00 PM
Michael Pluth, Ph.D., Assistant Professor of Organic Chemistry, Chemical Biology, Bioinorganic Chemistry, University of Oregon

Although historically known for its malodorous rotten egg smell, hydrogen sulfide (H2S) is now accepted as an important physiological mediator and signaling agent, joining CO and NO as an endogenous gasotransmitter. In its recent emergence as an impo more  »


From dynamically self-assembling materials to chemical reactivity in confined environments

Wednesday, November 4, 2015, 4:00 PM - 5:00 PM
Rafal Klajn, Ph.D., Senior Scientist / Assistant Professor, Weizmann Institute of Science

Living organisms are the most prominent examples of systems self-assembled and performing useful functions under far-from-equilibrium conditions. Inspired by nature, we design new materials whose structures and functions can be adjusted on demand, us more  »


CANCELLED - “Mapping the Energy Landscape of an RNA Tetraloop”

Tuesday, November 3, 2015, 12:30 PM - 1:30 PM
Angel Garcia, Director, Center for Nonlinear Studies, Los Alamos National Laboratory

Abstract: RNA molecules are able to adopt multiple folded conformation in response to the context in a larger molecule and the solution environment. We study the energy landscape of a simple RNA hairpin using molecular dynamics simulations. In partic more  »



In How Far Can We Make Nanoparticles Mimic Molecules?

Wednesday, October 28, 2015, 4:00 PM
Zhihong Nie, Ph.D., Assistant Professor of Chemistry, University of Maryland, College Park

The past decades have witnessed remarkable success in the synthesis of inorganic nanoparticles with interesting optical, electronic, or magnetic properties. Realizing the enormous potential of nanoparticles in such as energy, biomedical, and optoelec more  »


“Network-based Modeling of Epithelial to Mesenchymal Transition”

Tuesday, October 27, 2015, 12:30 PM - 1:30 PM
Réka Albert, Distinguished Professor of Physics and Biology, Department of Physics, The Pennsylvania State University

Abstract: Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by cancer cells to leave the primary tumor site. A hallmark of EMT is the loss of E-cadherin expression, and one major signal for the induction of EMT is transfo more  »


CGSA CAREER SEMINAR: Restoring Control to the Translational Landscape with Disciplined Chemistry

Friday, October 23, 2015, 4:00 PM - 5:00 PM
Siegfried Reich, Ph.D., Co-founder & Senior Vice President, Research at eFFECTOR Therapeutics, Inc.

Dysregulated translational control can lead to aberrant cellular function and disease and is a critical feature of cancer initiation and progression. Activation of key oncogenic pathways promotes rapid and significant translational reprogramming, not more  »


Restoring Control to the Translational Landscape with Disciplined Chemistry

Friday, October 23, 2015, 4:00 PM - 5:00 PM
Dysregulated translational control can lead to aberrant cellular function and disease and is a critical feature of cancer initiation and progression. Activation of key oncogenic pathways promotes rapid and significant translational reprogramming, not more  »


“Chromatin Structure and Nucleosome Stability in Drosophila Melanogaster”

Thursday, October 22, 2015, 12:30 PM - 1:30 PM
Alexandre V. Morozov, Associate Professor, Rutgers University, Department of Physics & Astronomy

Abstract: Nucleosomal DNA is often thought to be uniformly inaccessible to DNA-binding factors and components of transcriptional machinery. However, digesting Drosophila chromatin with high and low concentrations of micrococcal nuclease (MNase, an en more  »


Gold Nanostars: A Tunable Plasmonic Tool for Highly Sensitive SERS-based Detection

Wednesday, October 21, 2015, 4:00 PM - 5:00 PM
Laura Fabris, Ph.D., Professor, Department of Materials Science and Engineering, Institute for Advanced Materials Devices and Nanotechnology, Rutgers University

Near field techniques, such as surface enhanced Raman spectroscopy (SERS), rely on the ability of plasmonic nanoparticles to induce localized electromagnetic field enhancements in close proximity to the metallic surface. The possibility of achieving more  »

Lecture/Lecture Series

FRANKLIN LECTURE: How to Model the Action of Complex Biological Systems on a Molecular Level?

Wednesday, October 14, 2015, 4:00 PM - 5:00 PM
Arieh Warshel, Ph.D., Distinguished Professor of Chemistry, Fellow of the National Academy of Science, University of Southern California

Despite the enormous advances in structural studies of biological systems we are frequently left without a clear structure function correlation and cannot fully describe how different systems actually work. This introduces a major challenge for compu more  »


D. E. Shaw Research Information Session

Tuesday, October 13, 2015, 4:00 PM - 6:00 PM
Gennette Gill, Ph.D.
Ellen Zhong

D. E. Shaw Research is an independent research laboratory that conducts basic scientific research in the field of computational biochemistry under the direct scientific leadership of Dr. David E. Shaw. Our group is currently focusing on molecular si more  »


Pot economy and organocatalyst in total synthesis

Tuesday, October 13, 2015, 4:00 PM - 5:00 PM
Yujiro Hayashi, Ph.D., Professor of Chemistry, Tohoku University

Our group has an interest in the development and application of novel organocatalysts to asymmetric reac¬tions. In 2005, our group and Jørgensen’s group independently developed diphenylprolinol silyl ether. This catalyst is re¬garded as a useful asy more  »


The Energetic Ear

Tuesday, October 13, 2015, 12:30 PM - 1:30 PM
James Hudspeth, Investigator, Howard Hughes Medical Institute, F.M. Kirby Professor, Laboratory of Sensory Neuroscience

Abstract: As the gateway to human communication, the sense of hearing is of enormous importance in our lives. Research on hearing has recently been revolutionized by the demonstration that the ear is not simply a passive receiver for sound, but also more  »


From the mole to the molecule: nanocatalysis, one molecule at a time

Wednesday, October 7, 2015, 4:00 PM - 5:00 PM
Juan Scaiano, Ph.D., Professor and holder of the Canada Research Chair in Applied Photochemistry, University of Ottawa

Organic photochemistry is an excellent tool for the production of nanostructures of gold, silver, copper, cobalt, niobium, and other elements, Among photochemical precursors, ketones are good photosensitizers for nanoparticle synthesis because of the more  »

Thesis Defense

Optimization of coarse-grained molecular dynamics potentials for protein folding

Wednesday, October 7, 2015, 2:00 PM - 4:00 PM
Bobby Kim, Doctoral Candidate

This thesis discusses recent results using the Associative-memory, Water-mediated, Structure and Energy Model (AWSEM), an optimized, coarse-grained molecular dynamics model. AWSEM and its membrane protein extension, AWSEM-membrane, are capable of de more  »


Microtubule Severing Surprisingly Stymied

Tuesday, October 6, 2015, 12:30 PM - 1:30 PM
Jennifer Ross, Associate Professor, Department of Physics, University of Massachusetts Amherst

Abstract: Proper organization of the microtubule cytoskeletal network is required to perform many necessary cellular functions including mitosis, cell development, and cell motility. Network organization is achieved through filament remodeling by mic more  »