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Structure, Biosynthesis, and Mechanism of Small-Molecule Signals Controlling Nematode Development

Wednesday, September 28, 2016, 4:00 PM - 5:00 PM
Rebecca Butcher, Assistant Professor, University of Florida

Our goal is to develop a comprehensive understanding of the chemical structures, biosynthesis, and mechanism of secondary metabolites in nematodes. Caenorhabditis elegans secretes ascarosides, derivatives of the 3,6-dideoxysugar ascarylose, as pher more  »


“Immune Recognition, Antagonism and Phenotypic Spandrel”

Tuesday, September 27, 2016, 12:30 PM - 1:30 PM
Paul François, Associate Professor, Physics Department, McGill University

Abstract: In silico evolution can be used to predict design features of networks. The important problem of early immune response, to discriminate between self from not self, is considered. Rounds of evolution with different constraints uncover elabor more  »


How to Turn a Right Hand Into Left: Chiral Plasmons and More

Wednesday, September 21, 2016, 4:00 PM - 5:00 PM
V. Ara Apkarian, Professor of Chemisty, University of California, Irvine

Although chirality is recognized as the universal asymmetry which plays a fundamental role in chemistry, biology, physics, and life on earth, its rigorous quantification remains illusive. Since Lord Kelvin's definition of structural chirality as brok more  »


“A Chink in the Armour: Dynamic Structural Defects in Fibrillar Collagen Enable Collagenase Degradation”

Tuesday, September 20, 2016, 12:30 PM - 1:30 PM
Keir C. Neuman, Senior Investigator, National Heart, Lung and Blood Institute, National Institutes of Health

Abstract: Collagen is the main component of the extracellular matrix. Fibrillar collagen is resistant to proteolysis and is degraded by specific matrix metalloproteases (MMPs). The process of fibrillar collagen degradation remains poorly understood. more  »


Illuminating Metals: Fluorescent Tools for the Study of Cellular Magnesium Homeostasis

Wednesday, September 14, 2016, 4:00 PM - 5:00 PM
Daniela Buccella, New York University

Magnesium is the most abundant divalent cation in mammalian cells, with multiple roles that are essential for cellular function. Disrupted homeostasis of this metal has been associated with various pathologies including age-related diseases, neurodeg more  »


“Life at the Interface is Occasionally Unstable”

Tuesday, September 13, 2016, 12:30 PM - 1:30 PM
Ashutosh Agrawal, Assistant Professor, Department of Mechanical Engineering, University of Houston

Abstract: Biological membranes separate cells and organelles from their surrounding environment thus defining their identity. They maintain different chemical environments within and outside the cell while allowing continuous transport of nutrients i more  »


“Protein Fluctuations in Single Cells and Population Variability”

Tuesday, September 6, 2016, 12:30 PM - 1:30 PM
Hanna Salman, Associate Professor, Department of Physics & Astronomy University of Pittsburgh

Abstract: Protein copy-number varies among cells even in a genetically homogenous population. This variation causes changes in the shape, structure and behavior of individuals within the population. Characterizing and understanding this variation is more  »



“Target DNA Search by Proteins: A Needle-In-a-Haystack Problem?”

Tuesday, August 30, 2016, 12:30 PM - 1:30 PM
Junji Iwahara, Associate Professor, University of Texas, Medical Branch

Abstract: When transcription factors and DNA repair/modifying enzymes perform their function, these molecules must first locate their specific target sites in the vast presence of nonspecific but structurally similar sites on DNA. We are trying to be more  »

Thesis Defense

Fabrication of Organized Anisotropic Materials via Evaporative Self-Assembly

Friday, August 26, 2016, 3:00 PM - 5:00 PM
Paul Derry, Doctoral Candidate

This thesis describes progress towards the fabrication of macroscopically large, organized structures made from anisotropic nanomaterials using evaporative self-assembly. Chapter 1 is a literature overview of the characteristics and applications of s more  »

Thesis Defense

Nanomaterials for X-ray imaging and image-guided therapy applications

Thursday, August 25, 2016, 2:00 PM - 4:00 PM
Mayra Hernández Rivera, Doctoral Candidate

In recent years, nanomaterials have been explored for a wide range of different applications. Their tunable size and composition allow them to cross cellular membranes, and therefore, various nanomaterials have been used for a diversity of medical ap more  »


Reactive Oxygen Species (ROS) and Their Applications to Photodynamic Therapy

Wednesday, August 24, 2016, 4:00 PM - 5:00 PM
Alexander Greer, Brooklyn College of the City University of New York

This lecture describes studies of interfacial ROS, in particular the reactive species singlet oxygen (1O2). Studies of alkene surfactants with airborne 1O2 at the air-water interface led to regioselective formation of surfactant hydroperoxides. Preny more  »


“Metastable Mesoscopic Clusters: A Novel Class of Protein Aggregates”

Tuesday, August 23, 2016, 12:30 PM - 1:30 PM
Peter G. Vekilov, John and Rebecca Moores Professor, University of Houston

Abstract: Protein-rich clusters of steady submicron size and narrow size distribution exist in protein solutions in apparent violation of the classical laws of phase equilibrium. Even though they contain a minor fraction of the total protein, eviden more  »