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Gang Bao

Foyt Family Professor of Bioengineering

Publications

J. Zhao, I. Akinsanmi1, D. Arafat, T. J. Cradick, C. M. Lee, S. Banskota, G. Bao, and G. Gibson. A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood, The American J. Human Genetics, in press (2015).

C.A. Quinto, P. Mohindra, S. Tong, G. Bao*, “Multifunctional Superparamagnetic Iron Oxide Nanoparticles for Combined Chemotherapy and Hyperthermia Cancer Treatment”, Nanoscale, 7, 12728-12736 (2015).

Y. Yang, J. Ran, L. Sun, X. Sun, Y. Luo, B. Yan, Tala, M. Liu, D. Li, L. Zhang, G. Bao*, J. Zhou*, “CYLD regulates noscapine activity in acute lymphoblastic leukemia via a microtubule-dependent mechanism”, Theranostics, 5, 656-66 (2015)

L. Minati, V. Antonini, C. Pederzolli, M. Dalla Serra, G. Bao, G. Speranza*, “Combinatorial plasma polymerization: C-based films”, Encyclopedia of Plasma Technology, in press (2015).

R. N. Cottle, C. M. Lee, D. Archer and G. Bao*, “Controlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjection” Scientific Reports, 5, 16031 (2015).

T. A. Meyer, C. A. Quinto, G. Bao*, “Controlling Iron Oxide Nanoparticle Clustering Using Dual Solvent Exchange Coating Method”, IEEE Magnetics Letters, in press (2015).

M. Aouida, A. Eid, Z. Ali, T. J. Cradick, H. Deshmukh, A. Atef, D. B. AbuSamra, C. M. Lee, S. Z. Gadhoum, J. S. Merzaban, G. Bao and M. M. Mahfouz*, “Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering”, PLoS One, 10, e0133373 (2015). 

J. Corrigan-Curay, M. O’Reilly, D.B. Kohn, P.M. Cannon, G. Bao et al, “Genome Editing Technologies: Defining a Path to Clinic”, Molecular Therapies, 23, 796-806 (2015). 

S. L. Zhang*, H. J. Gao* and G. Bao*.  “Mechanics of Endocytosis”, ACS Nano, 9, 8655-71 (2015).

R. Jhaa, B. Wile, Q. Wu, A. H. Morris, K. O. Maher, M. B. Wagner, G. Bao*, C. Xu*, “Molecular Beacon-based Detection and Isolation of Working-type Cardiomyocytes Derived from Human Pluripotent Stem Cells”, Biomaterials 50, 176-85 (2015).

K. Ban, PhD, B. Wile, K. W. Cho, S. Kim, M. K. Song, J. Singer, A. Syed, S. P. Yu, M. Wagner, G. Bao* and Y. S. Yoon*, “Non-genetic purification of ventricular cardiomyocytes from differentiating embryonic stem cells through molecular beacons targeting a ventricle-specific transcription factor”, Stem Cell Reports, 5, 1239-49 (2015).

A. Hendel, E. J. Fine, G. Bao, M. H. Porteus*, “Quantifying On and Off-Target Genome Editing”, Trends in Biotechnology, 33, 132-40 (2015).

J. Giraldo-Vela, W. Kang, R. McNaughton, X. Zhang, B. Wile, A. Tsourkas, G. Bao, H. Espinosa*, “Single-Cell Detection of mRNA Expression Using Nanofountain-Probe Electroporated Molecular Beacons”, Small, 11, 2386-91 (2015).

M. Müller, C. M. Lee, G. Gasiunas, T. Davis, T. J. Cradick, V. Siksnys, G. Bao, C. Mussolino, T. Cathomen, “Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome”, Molecular Therapy, 2015 Dec 14. doi: 10.1038/mt.2015.218. [Epub ahead of print] (2015).

S. Suzuki, G. Sargent, B. Illek, H. Fischer, A. Esmaeili-Shandiz, M. J. Yezzi, A. Lee, Y. Yang, S. Kim, P. Renz, Z. Qi, J. Yu, M. O. Muench, A. I. Beyer, A. O. Guimarães, L. Ye, J. Chang, E. J. Fine, T. J. Cradick, G. Bao, M. Rahdar, M. H. Porteus, T. Shuto, H. Kai, Y. W. Kan, D. C. Gruener*, “TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs”, Molecular Therapy Nucleic Acids, 5, e273 (2016). 

N. Hoshyar, S. Gray, H. Han, G. Bao*, “The Effect of Nanoparticle Size on In vivo Pharmacokinetics and Cellular Interaction”, Nanomedicine, in press (2015). 

E. J. Fine, C. Appleton, M. Brown, H. Deshmukh and G.Bao*, “Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human HEK-293T cells: a first step towards AAV packaging”, Scientific Reports, 5, 10777 (2015).

C. M. Lee, T. H. Davis and G. Bao* Examination of CRISPR/Cas9 design tools and the effect of target site accessibility on Cas9 activity.  Experimental Physiology March 16, 2017

K. E. Jarretta, C. M. Lee, Y. H. Yeh, R. H. Hsu, R. Gupta, M. Zhang, P. J. Rodriguez, C. S. Lee, B. K. Gillard, K. D. Bissig, H. J. Pownall, J. F. Martin, G. Bao, W. R. Lagor* Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease.  Scientific Reports, 7 March 16, 2017: 44624

M. Li, S. Chakraborty, C. M. Lee, H-W Kim, G. Bao, F. Zhang and K. W. Leong* CRISPR/Cas9-based genome editing for disease modeling and therapy: Challenges and opportunities for nonviral delivery.  Chemical Reviews June 22, 2017

H. F Tsai, A. Trubelja, A. Q. Shen* and G. Bao* Tumor-on-a-chip: microfluidic models of tumor morphology, growth, and microenvironment.  J. Royal Soc. Interface, 131 June 14, 2017

H. Zhu, S. Tong, C. M. Lee, L. Zhang, T. H. Davis, H. Deshmukh, Z. Zhang, L. Hong and G. Bao* Nanomagnets Enable Spatiotemporal Control of In Vivo Genome Editing with CRISPR/Cas9.  Nature Biomedical Engineering 2017 in revision

C. A. Vakulskas, D. P. Dever, G. R. Rettig, R. Turk, A. M. Jacobi, M. A. Collingwood, N. M. Bode, M. S. McNeill, S. Yan, J. Camarena, C. M. Lee, S. H. Park, V. Wiebking, R. O. Bak, N. Gomez-Ospina, M. Pavel-Dinu, W. Sun, G. Bao, M. H. Porteus, M. A. Behlke A novel high-fidelity Cas9 variant enables high frequency correction of a disease-causing SNP in human haematopoietic stem and progenitor cells.  Nature Medicine 2017

D. Gomes-Silva, M. Srinivasan, S. Sharma, C. M. Lee, T. H. Davis, R. H. Rouce, G. Bao, M. K. Brenner, and M. Mamonkin* CD7-edited T cells Expressing a CD7-specific CAR for the Therapy of T-cell Malignancies.  Blood, 130(3) 2017: 285-296

H. Butt, A. Eid, Z. Ali, M. Atia, M. M. Mokhtar, N. Hassan, C. M. Lee, G. Bao and M. M. Mahfouz* Efficient CRISPR/Cas9-mediated genome editing using a chimeric single-guide RNA molecule.  Front Plant Sci, 8 2017: 1441

J. L. Schneller, C. M. Lee, G. Bao and C. P. Venditti* Genome Editing for Inborn Errors of Metabolism: Advancing Towards the Clinic.  BMC Medical Genomics, 15(1) 2017: 43

M. Pavel-Dinu, V. A. Wiebking, B. T. Dejene, W. Srifa, S. Mantri, C. E. Nicolas, C. Lee, G. Bao, E. J. Kildebeck, N. Punjya, C. Sindhu, K. I. Weinberg, S. S. DeRavin, H. Malech, M. G. Roncarolo, M. H. Porteus Genome editing of long-term human hematopoietic stem cells for SCID-X1.  Science 2017

S. H. Park, C. M. Lee, D. P. Dever, T. H. Davis, J. Camarena, Y. Zhang, M. H. Porteus, V. A. Sheehan* and G. Bao* Highly Efficient Genome Editing of the Beta-globin Locus in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease.  Nature Biomedical Engineering 2017

Y. Qiu, S. Tong, L. Zhang, Y. Sakurai, D. Myers, L. Hong, W. Lam* and G. Bao* Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions.  Nature Communications, 8 2017: 15594

A. M. James, M. B. Baker, G. Bao, and C. D. Searles* MicroRNA Detection Using a Double Molecular Beacon Approach: Distinguishing Between miRNA and Pre-miRNA.  Theranostics, 7(3) 2017: 634-646

S. Tong, C. A. Quinto, L. Zhang, P. Mohindra and G. Bao* Size-dependent Ultra-efficient Heating by Magnetic Iron Oxide Nanoparticles.  ACS Nano, 11(7) 2017: 6808-6816

Gang Bao Profile
Bao Lab website

  • B.Sc. Mechanical Engineering (1976) Shandong University
  • Ph.D. Applied Mathematics (1987) Lehigh University
  • M.Sc. Applied Mechanics (1981) Shandong University
  • Department of Bioengineering
  • nanoparticles, cancer, genome editing
Email: Gang.Bao@rice.edu
Phone: 713-348-2764
Office: BioScience Research Collaborative , 413