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Protein Folding and Functional Dynamics



By: Feng Gai
Edmund J. and Louise W. Kahn Endowed Term Professor of Chemistry
From: University of Pennsylvania
When: Wednesday, November 19, 2014
4:00 PM - 5:00 PM
Where: Founder's Court
Abstract: Proteins can undergo various conformational transitions. Due to the multidimensional nature of the underlying conformational energy landscape and the fact that protein structural motions can occur over a wide range of timescales, it is often difficult to directly probe and delineate the conformational event of interest with high temporal and structural resolution. In this talk, several examples will be discussed to demonstrate how linear and nonlinear spectroscopic techniques, in conjunction with site-specific infrared and fluorescence probes, can improve our ability to scrutinize the molecular details of protein folding and functional dynamics.